Halo Uprising follows Master Chief on the Forerunner Dreadnought, as well as Ruwan Ackerson, and Myras Tyla.
It follows Master Chief's activities on his way to earth, as well as how he gets off of the Dreadnought.
It also tells the story of when the Covenant attacks Cleveland, and why they didn't destroy it. They had captured Colonel James Ackerson, and told him that they were going to destroy Earth. And in an attempt to save his brother, Ruwan, he lied to the Brutes, and said there was something in Cleveland, Ohio that they couldn't fire the Halo Array without. The "Key of Osanalan", he called it. Of course, the Key was fake. Him and Ruwan made it up when playing together. When the Covenant invaded Cleveland, demanding the location of the Key from it's citizens, Ruwan heard the name, and knew it was James. Ruwan eventually makes it to a UNSC outpost, and meets with the Covenant, saying he was the Key. He was then sent to the Minister of Inquisition. Before meeting with the Covenant, he was injected with a tracking substance. The plan was that he would become a target. Once he was on the CCS-class Battlecruiser, the Orbital Defense Platform Nassau used its MAC to destroy it. Ruwan, and everyone else on it died.
Uprising wasn't my favorite comic. So far, I've only read Uprising, Helljumper, and Halo Graphic Novel. Helljumper is my favorite at this point. The story was ok, but I didn't care for the drawings. I really liked Helljumper's art. I wouldn't recommend anyone to buy this for more than $2, unless they're a hardcore Halo/comic fan. I just checked it out of the library, and that's what I recommend you do, if not, borrow it from a friend.